Article
Francisella tularensis molecular typing using differential insertion sequence amplification.
Journal of clinical microbiology - 1 Aug 2011
Larson Marilynn A, Fey Paul D, Bartling Amanda M, Iwen Peter C, Dempsey Michael P, Francesconi Stephen C, Hinrichs Steven H
Abstract excerpt
Tularemia is a potentially fatal disease that is caused by the highly infectious and zoonotic pathogen Francisella tularensis. Despite the monomorphic nature of sequenced F. tularensis genomes, there is a significant degree of plasticity in the organization of genetic elements. The observed variability in these genomes is due primarily to the transposition of direct repeats and insertion sequence (IS) elements....
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