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Article

No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women.

Acta pharmacologica Sinica - 1 Jul 2011

Hu Wei-wei, He Jin-wei, Zhang Hao, Wang Chun, Gu Jie-mei, Yue Hua, Ke Yao-hua, Hu Yun-qiu, Fu Wen-zhen, Li Miao, Liu Yu-juan, Zhang Zhen-lin

Abstract excerpt

AIM: To study whether genetic polymorphisms of COL1A1 and COL1A2 genes affected the onset of fracture in postmenopausal Chinese women. METHODS: SNPs in COL1A1 and COL1A2 genes were identified via direct sequencing in 32 unrelated postmenopausal Chinese women. Ten SNPs were genotyped in 1252 postmenopausal Chinese women. The associations were examined using both single-SNP and haplotype tests using logistic...

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PMID: 21602843
DOI: 10.1038/aps.2011.37
PMCID: PMC4003126

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