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Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin

21 May 2011

Abstract excerpt

BACKGROUND: The genus Nairovirus in the family Bunyaviridae contains 34 tick-borne viruses classified into seven serogroups. Hazara virus (HAZV) belongs to the Crimean-Congo hemorrhagic fever (CCHF) serogroup that also includes CCHF virus (CCHFV) a major pathogen for humans. HAZV is an interesting model to study CCHFV due to a close serological and phylogenetical relationship and a classification which allows...

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PMID: 21600011
DOI: 10.1186/1743-422x-8-249

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