Article
Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Jun 2011
Pileckyte Regina, Jurgutis Mindaugas, Valceckiene Vilma, Stoskus Mindaugas, Gineikiene Egle, Sejoniene Jurgita, Degulys Andrius, Zvirblis Tadas, Griskevicius Laimonas
Abstract excerpt
This study evaluated the efficacy and safety of dose-dense high-dose methylprednisolone (HDMP) plus rituximab (Rtx) in patients with high-risk CLL. Twenty-nine patients with relapsed or progressive CLL with adverse cytogenetics (17p deletion, TP53 mutation, 11q deletion, and/or trisomy 12) and/or progression within 12 months of fludarabine treatment were included. HDMP (1 g/m(2)) was administered daily for 5 days...
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