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Article

Bone cell autophagy is regulated by environmental factors.

Cells, tissues, organs - 1 Jan 2011

Zahm Adam M, Bohensky Jolene, Adams Christopher S, Shapiro Irving M, Srinivas Vickram

Abstract excerpt

The goal of this investigation was to ascertain whether bone cells undergo autophagy and to determine if this process is regulated by environmental factors. We showed that osteocytes in both murine and human cortical bone display a punctuate distribution of microtubule-associated protein light chain 3, indicative of autophagy. In addition, we noted a basal level of autophagy in preosteocyte-like murine long...

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Identifiers

PMID: 21597271
DOI: 10.1159/000324647
PMCID: PMC3178090

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