Article
MicroRNA sequence and expression analysis in breast tumors by deep sequencing.
Cancer research - 1 Jul 2011
Farazi Thalia A, Horlings Hugo M, Ten Hoeve Jelle J, Mihailovic Aleksandra, Halfwerk Hans, Morozov Pavel, Brown Miguel, Hafner Markus, Reyal Fabien, van Kouwenhove Marieke, Kreike Bas, Sie Daoud, Hovestadt Volker, Wessels Lodewyk F A, van de Vijver Marc J, Tuschl Thomas
Abstract excerpt
MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing seed sequence-dependent miRNA target regulation....
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