Article
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae.
The Journal of cell biology - 16 May 2011
Mao Kai, Wang Ke, Zhao Mantong, Xu Tao, Klionsky Daniel J
Abstract excerpt
Macroautophagy (hereafter referred to simply as autophagy) is a catabolic pathway that mediates the degradation of long-lived proteins and organelles in eukaryotic cells. The regulation of mitochondrial degradation through autophagy plays an essential role in the maintenance and quality control of this organelle. Compared with our understanding of the essential function of mitochondria in many aspects of cellular...
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