Article
The Epstein-Barr virus BRLF1 immediate-early gene product transactivates the human immunodeficiency virus type 1 long terminal repeat by a mechanism which is enhancer independent.
Journal of virology - 1 Apr 1990
Quinlivan E B, Holley-Guthrie E, Mar E C, Smith M S, Kenney S
Abstract excerpt
The Epstein-Barr virus (EBV) immediate-early gene product, BRLF1, transactivates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat. BRLF1-induced transactivation of HIV-1 promoter constructs is accompanied by an increase in plasmid mRNA and is reporter gene independent. Previously, BRLF1 transactivation of EBV promoters has been mapped to regions which function as enhancer elements. Deletional...
Topics
- Antigens, Viral
- Cell Line
- Enhancer Elements, Genetic
- HIV-1
- Herpesvirus 4, Human
- Humans
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- RNA, Viral
- Repetitive Sequences, Nucleic Acid