Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transendocardial Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus Macaques

13 May 2011

Abstract excerpt

Heart disease is the leading cause of morbidity and mortality, and cardiac gene transfer has potential as a novel therapeutic approach. We previously demonstrated safe and efficient gene transfer to the canine heart using a percutaneous transendocardial injection procedure to deliver self-complementary (sc) adeno-associated virus 6 (AAV6) vector. In the present study, we proceed with our vertical translation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral Infections and Immunology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21563985
DOI: 10.1089/hum.2011.042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transendocardial Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus MacaquesPMID 21563985Read ↗

Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in CaninesSemantic proximity Read ↗

Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene TransferSemantic proximity Read ↗

An Emerging Adeno-Associated Viral Vector Pipeline for Cardiac Gene TherapySemantic proximity Read ↗

Comparative Cardiac Gene Delivery of Adeno‐Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse HeartSemantic proximity Read ↗

AAV Vectors for Cardiac Gene Transfer: Experimental Tools and Clinical OpportunitiesSemantic proximity Read ↗

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and RatSemantic proximity Read ↗

Cardiac gene therapy with adeno-associated virus-based vectorsSemantic proximity Read ↗

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8Semantic proximity Read ↗

Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primatesSemantic proximity Read ↗

Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal ModelsSemantic proximity Read ↗

Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In VivoSemantic proximity Read ↗

Targeting the heart with gene therapy-optimized gene delivery methodsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.