Article
Biomarkers in frontotemporal lobar degenerations--progress and challenges.
Progress in neurobiology - 1 Dec 2011
Hu William T, Trojanowski John Q, Shaw Leslie M
Abstract excerpt
Neuronal and glial changes associated with tau, TAR DNA binding protein of ∼43 kDa (TDP-43), and fused in sarcoma (FUS) together constitute the pathologic spectrum of frontotemporal lobar degeneration (FTLD). Most patients with FTLD present with prominent behavior or language changes, sometimes accompanied by extrapyramidal symptoms or motor neuron disease. Identification of FTLD patients with mutations in genes...
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