Article
Bevacizumab in combination with cetuximab and irinotecan after failure of cetuximab and irinotecan in patients with metastatic colorectal cancer.
Acta oncologica (Stockholm, Sweden) - 1 May 2011
Larsen Finn Ole, Pfeiffer Per, Nielsen Dorte, Skougaard Kristin, Qvortrup Camilla, Vistisen Kirsten, Fromm Anne-Lene, Jørgensen Trine L, Bjerregaard Jon K, Hoegdall Estrid, Jensen Benny V
Abstract excerpt
BACKGROUND: The efficacy and safety of concurrent administration of irinotecan with the two monoclonal antibodies cetuximab and bevacizumab as fourth line therapy in heavily pretreated patients with metastatic colorectal cancer were evaluated. PATIENTS AND METHODS: Patients with metastatic colorectal cancer who had progressed on therapy with 5-FU, oxaliplatin and irinotecan in the first and second line setting...
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