Article
The induction of α-helical structure in partially unfolded HypF-N does not affect its aggregation propensity.
Protein engineering, design & selection : PEDS - 1 Jul 2011
Ahmad B, Vigliotta I, Tatini F, Campioni S, Mannini B, Winkelmann J, Tiribilli B, Chiti F
Abstract excerpt
The conversion of proteins into structured fibrillar aggregates is a central problem in protein chemistry, biotechnology, biology and medicine. It is generally accepted that aggregation takes place from partially structured states of proteins. However, the role of the residual structure present in such conformational states is not yet understood. In particular, it is not yet clear as to whether the α-helical...
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