Article
The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.
Circulation. Cardiovascular genetics - 1 Apr 2011
Sun Albert Y, Koontz Jason I, Shah Svati H, Piccini Jonathan P, Nilsson Kent R, Craig Damian, Haynes Carol, Gregory Simon G, Hranitzky Patrick M, Pitt Geoffrey S
Abstract excerpt
BACKGROUND: Risk-stratifying heart failure patients for primary prevention implantable cardioverter-defibrillators (ICDs) remains a challenge, especially for blacks, who have an increased incidence of sudden cardiac death but have been underrepresented in clinical trials. We hypothesized that the S1103Y cardiac sodium channel SCN5A variant influences the propensity for ventricular arrhythmias in black patients...
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