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Article

Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture.

Journal of neurovirology - 1 Jun 2011

Brazeau Elizabeth, Wellish Mary, Kaufer Benedict B, Tischer B Karsten, Gray Wayne, Zhou Fuchun, Osterrieder Nikolaus, Hanlon Teri, Golive Anjani, Hall Travis, Nair Sreekala, Owens Gregory P, Mueller Niklaus H, Cohrs Randall J, Pugazhenthi Subbiah, Gilden Don, Mahalingam Ravi

Abstract excerpt

Simian varicella virus (SVV) open reading frame (ORF) 63, duplicated in the virus genome as ORF 70, is homologous to varicella zoster virus ORF 63/70. Transfection of bacterial artificial chromosome clones containing the wild-type SVV genome and mutants with stop codons in ORF 70, in both ORFs 63 and 70 and the repaired virus DNA sequences into Vero cells produced a cytopathic effect (CPE). The onset of CPE was...

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Identifiers

PMID: 21479719
DOI: 10.1007/s13365-011-0025-6
PMCID: PMC3204661

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture.PMID 21479719Read ↗

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