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Article

Influence of HLA phenotypes on the inhibition of in vitro alloreactivity by cyclosporine.

Transplantation - 1 Dec 1990

Zlabinger G J, Pohanka E, Hajek-Rosenmayr A, Pavlicek E, Watschinger B, Traindl O, Kovarik J

Abstract excerpt

Interindividual variations in the immunosuppressive effect of Cyclosporine have been observed in clinical organ transplantation. Searching for an in vitro correlate we investigated a possible relation between inhibition of alloresponsiveness by CsA and the HLA phenotypes of the responder or stimulator in mixed lymphocyte reactions. Peripheral blood mononuclear cells from 28 healthy volunteers were used as...

Topics

Cyclosporins
HLA-DR Antigens
Humans
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2147791
DOI: 10.1097/00007890-199012000-00027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2147791-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Influence of HLA phenotypes on the inhibition of in vitro alloreactivity by cyclosporine.PMID 2147791Read ↗

Evidence that sensitivity to cyclosporine is influenced by the HLA-DR phenotype of kidney graft recipients.Semantic proximity Read ↗

Individual variability in cyclosporin A sensitivity: the assessment of functional measures on CD28-mediated costimulation of human whole blood T lymphocytes.Semantic proximity Read ↗

Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression.Semantic proximity Read ↗

The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigens.Semantic proximity Read ↗

Genetic conditioning of the in vitro human lymphocyte sensitivity to cyclosporin-A.Semantic proximity Read ↗

Donor specific HLA antibody in hematopoietic stem cell transplantation: Implications for donor selectionSemantic proximity Read ↗

Understanding the alloresponse: New approaches to graft-versus-host disease preventionSemantic proximity Read ↗

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