Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts.

Abstract excerpt

Oral tongue cancer is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. Treatment options for this cancer are limited. However, gene therapy has attracted keen interest as a new strategy for refractory cancer. The aim of this study was to examine the efficiency of transfection of the exogenous p27Kip1 gene by electroporation and the antitumor activity of...

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