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Article

Mesenchymal stem cells as vehicles for targeted delivery of anti-angiogenic protein to solid tumors.

The journal of gene medicine - 1 Mar 2011

Ghaedi Mahboobe, Soleimani Masoud, Taghvaie Narges Mohammad, Sheikhfatollahi Mahmood, Azadmanesh Keyhan, Lotfi Abbas S, Wu Jian

Abstract excerpt

BACKGROUND: Inhibition of tumor-induced angiogenesis may restrict tumor growth and metastasis. Long-term systemic delivery of angiogenic inhibitors is associated with toxicity, as well as other severe side-effects. The utility of cells as vehicles for gene therapy to deliver therapeutic molecules has been suggested to represent an efficient approach. Mesenchymal stem cells (MSCs) exhibit a tropism to cancer...

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Identifiers

PMID: 21449040
DOI: 10.1002/jgm.1552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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