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Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing

17 Mar 2011

Abstract excerpt

The fungal pathogen Candida glabrata has risen from an innocuous commensal to a major human pathogen that causes life-threatening infections with an associated mortality rate of up to 50%. The dramatic rise in the number of immunocompromised individuals from HIV infection, tuberculosis, and as a result of immunosuppressive regimens in cancer treatment and transplant interventions have created a new and hitherto...

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PMID: 21445236
DOI: 10.1371/journal.ppat.1001322

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