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Article

Common variation in GPC5 is associated with acquired nephrotic syndrome.

Nature genetics - 1 May 2011

Okamoto Koji, Tokunaga Katsushi, Doi Kent, Fujita Toshiro, Suzuki Hodaka, Katoh Tetsuo, Watanabe Tsuyoshi, Nishida Nao, Mabuchi Akihiko, Takahashi Atsushi, Kubo Michiaki, Maeda Shiro, Nakamura Yusuke, Noiri Eisei

Abstract excerpt

Severe proteinuria is a defining factor of nephrotic syndrome irrespective of the etiology. Investigation of congenital nephrotic syndrome has shown that dysfunction of glomerular epithelial cells (podocytes) plays a crucial role in this disease. Acquired nephrotic syndrome is also assumed to be associated with podocyte injury. Here we identify an association between variants in GPC5, encoding glypican-5, and...

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Source

Identifiers

PMID: 21441931
DOI: 10.1038/ng.792

Genes

GPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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