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Article

Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model

25 Mar 2011

Abstract excerpt

BACKGROUND: Steroid sulfatase (STS) is involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of disease-free and endometriosis patients. The present study was designed to investigate its role in endometriosis development. METHODS: Human endometrial explants were cultured on inserts for 24 h to assess the effectiveness of an STS inhibitor (STS-I), estradiol-3-O-sulfamate (E2MATE), on...

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PMID: 21441545
DOI: 10.1093/humrep/der079

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