Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The first use of EaeI restriction enzyme in DNA diagnosis of Hb Q-India.

International journal of laboratory hematology - 1 Oct 2011

Khalil M S M, Henderson S, Schuh A, Hussein M-R A, Old J

Abstract excerpt

INTRODUCTION: The α-chain variant Hb Q-India (c.193G>C) is caused by a point mutation GAC→CAC at codon 64 of the α1 globin gene and is clinically silent. Point mutations can be diagnosed easily by many simple polymerase chain reaction (PCR) techniques including PCR-restriction digest, but for Hb Q-India the restriction digest has never been described. In this work we aimed to develop a restriction enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Globins
Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Hemoglobinopathies

Share to Hemoglobins, Abnormal

Share to Heterozygote

Share to Mutation

Share to Restriction Mapping

Source

Identifiers

PMID: 21435192
DOI: 10.1111/j.1751-553X.2011.01316.x

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The first use of EaeI restriction enzyme in DNA diagnosis of Hb Q-India.PMID 21435192Read ↗

A Wide Spectrum Study of α-Globin Chain Variants: Cases from the UK.Semantic proximity Read ↗

Identification of hemoglobin Q India (alpha 1-64 Asp-His) through ARMS-PCR. First report from Pakistan.Semantic proximity Read ↗

Case series of HbQ-India, a rare alpha globin variant in a referral laboratory setting in South India.Semantic proximity Read ↗

HbQ-India in a Sindhi family: an uncommon hemoglobin variant.Semantic proximity Read ↗

Hb Q-India: an uncommon variant diagnosed in three Punjabi patients with diabetes is identified by a novel DNA analysis test.Semantic proximity Read ↗

A novel polymorphism causes a different restriction pattern by RsaI in the beta-globin gene cluster: application in prenatal diagnosis.Semantic proximity Read ↗

The occurrence of beta-thalassemia mutation and its interaction with hemoglobin E in the eastern India.Semantic proximity Read ↗

Variable presentation of HB H disease due to homozygosity for the rare polyadenylation signal A T(Indian) (AATAAA>AATA- -) mutation in four Indian families.Semantic proximity Read ↗

Red cell enzyme polymorphisms in Muslim population of Eastern UP, IndiaSemantic proximity Read ↗

A simple approach to the characterization of three common Indian beta-thalassemia mutations by artificially created restriction sites.Semantic proximity Read ↗

Diagnosis of Hemoglobinopathies and thalassemias using both Haemoglobin capillary zone electrophoresis and High performance liquid chromatography - An experience from a tertiary care hospital in Northern IndiaSemantic proximity Read ↗

Detection of beta-thalassaemia mutations in eastern Indian population by polymerase chain reaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.