[Screening and analysis of the mutations on beta-myosin heavy chain gene in 3 Chinese families with hypertrophic cardiomyopathy].

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Article

[Screening and analysis of the mutations on beta-myosin heavy chain gene in 3 Chinese families with hypertrophic cardiomyopathy].

Zhonghua xin xue guan bing za zhi - 1 Feb 2011

Feng Xiu-li, Fan Xin-ping, Yang Zhong-wei, Yang Fu-hui

Abstract excerpt

OBJECTIVE: To detect gene mutations on beta-myosin heavy chain gene MYH7 in 3 Chinese families with hypertrophic cardiomyopathy (HCM), and to analyze the correlation between genotype and phenotype. METHODS: A denaturing high-performance liquid chromatography (DHPLC) and sequencing mutation screening of the exons (exon3-23) coding for MYH7 gene were performed in 3 Chinese families with HCM. RESULTS: In this study,...

Topics

Adolescent
Adult
Asian People
Cardiac Myosins
Cardiomyopathy, Hypertrophic, Familial
Case-Control Studies
Child
DNA Mutational Analysis
Exons
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Mutation

Myosin Heavy Chains

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 21426742

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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