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Article

Non-erythropoietic erythropoietin derivatives protect from light-induced and genetic photoreceptor degeneration.

Human molecular genetics - 1 Jun 2011

Colella Pasqualina, Iodice Carolina, Di Vicino Umberto, Annunziata Ida, Surace Enrico M, Auricchio Alberto

Abstract excerpt

Given the high genetic heterogeneity of inherited retinal degenerations (IRDs), a wide applicable treatment would be desirable to halt/slow progressive photoreceptor (PR) cell loss in a mutation-independent manner. In addition to its erythropoietic activity, erythropoietin (EPO) presents neurotrophic characteristics. We have previously shown that adeno-associated viral (AAV) vector-mediated systemic EPO delivery...

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Identifiers

PMID: 21421996
DOI: 10.1093/hmg/ddr115
PMCID: PMC3090200

Genes

EPO

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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