Article
Gender-specific interactions between alcohol metabolism genes and severity of quantitative alcohol-related-traits in a Tibetan population.
Neuroscience letters - 9 May 2011
Guo Wan-Jun, Wang Qiang, Lanzi Gongga, Luobu Ouzhu, Ma Xiao-Hong, Wang Ying-Cheng, Zhen Puo, Wei Geng, Deng Wei, Zhuoma Basang, Shi Xiao-Ming, Liu Xie-He, Wu Yue-Jing, Xu Yan, Collier David A, Ball David, Hu Xun, Li Tao
Abstract excerpt
Association between genes influencing alcohol metabolism and alcohol use disorders (AUD) has been extensively studied, but the effect of interactions between these genes and AUD have rarely been tested. Our previous case-control study in a Tibetan population noted that the positive association between c2 allele of cytochrome P4502E1 (CYP2E1) gene and AUD might only exist in males who are homozygotes for 1 alleles...
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