Article
Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer.
Journal of surgical oncology - 1 Apr 2011
Navarro Alfons, Diaz Tania, Gallardo Elena, Viñolas Nuria, Marrades Ramon M, Gel Bernat, Campayo Marc, Quera Angels, Bandres Eva, Garcia-Foncillas Jesus, Ramirez Jose, Monzo Mariano
Abstract excerpt
BACKGROUND: MicroRNAs are novel regulators of gene expression that are linked to the main oncogene networks, including the p53 pathway. p53 regulates the maturation process of miR-16 and miR-143. We analyzed the role as prognostic markers of miR-16 and miR-143 in 70 non-small-cell lung cancer (NSCLC) patients. METHODS: MicroRNAs were analyzed by TaqMan MicroRNA assays. Disease-free survival (DFS) and overall...
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