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Genetic elimination of dengue vector mosquitoes

7 Mar 2011

Abstract excerpt

An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was engineered to have a repressible female-specific flightless phenotype. This strain circumvents the...

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PMID: 21383140
DOI: 10.1073/pnas.1019295108

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