Article
Inhibition of Streptococcus mutans by the antibiotic streptozotocin: mechanisms of uptake and the selection of carbohydrate-negative mutants.
Infection and immunity - 1 Feb 1990
Jacobson G R, Poy F, Lengeler J W
Abstract excerpt
The antibiotic streptozotocin [2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranoside], an analog of N-acetylglucosamine (NAG), has been shown to be useful for the selection of carbohydrate-negative and auxotrophic bacterial mutants. We have adapted this method for use with the oral pathogen Stre...
Topics
- Acetylglucosamine
- Carbohydrate Metabolism
- Mutation
- Phosphorylation
- Streptococcus mutans
- Streptozocin