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Article

Aberrant DNA Methylation of Matrix Remodeling and Cell Adhesion Related Genes in Pterygium

16 Feb 2011

Abstract excerpt

BACKGROUND: Pterygium is a common ocular surface disease characterized by abnormal epithelial and fibrovascular proliferation, invasion, and matrix remodeling. This lesion, which migrates from the periphery to the center of the cornea, impairs vision and causes considerable irritation. The mechanism of pterygium formation remains ambiguous, and current treatment is solely surgical excision, with a significant...

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PMID: 21359202
DOI: 10.1371/journal.pone.0014687

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