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Article

C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPα confers susceptibility to UVB-induced skin squamous cell carcinomas.

The Journal of investigative dermatology - 1 Jun 2011

Thompson Elizabeth A, Zhu Songyun, Hall Jonathan R, House John S, Ranjan Rakesh, Burr Jeanne A, He Yu-Ying, Owens David M, Smart Robert C

Abstract excerpt

Human epidermis is routinely subjected to DNA damage induced by UVB solar radiation. Cell culture studies have revealed an unexpected role for C/EBPα (CCAAT/enhancer-binding protein-α) in the DNA damage response network, where C/EBPα is induced following UVB DNA damage, regulates the G(1) checkpoint, and diminished or ablated expression of C/EBPα results in G(1) checkpoint failure. In the current study we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21346772
DOI: 10.1038/jid.2011.31
PMCID: PMC3418815

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