Article
High-throughput assays for detection of the F1534C mutation in the voltage-gated sodium channel gene in permethrin-resistant Aedes aegypti and the distribution of this mutation throughout Thailand.
Tropical medicine & international health : TM & IH - 1 Apr 2011
Yanola Jintana, Somboon Pradya, Walton Catherine, Nachaiwieng Woottichai, Somwang Puckavadee, Prapanthadara La-aied
Abstract excerpt
OBJECTIVES: To develop rapid monitoring tools to detect the F1534C permethrin-resistance mutation in domain IIIS6 of the Aedes aegypti voltage-gated sodium channel gene and determine the frequency and distribution of this mutation in Thailand. METHODS: A TaqMan SNP genotyping and an allele specific PCR (AS-PCR) assay were developed and validated by comparison with DNA sequencing of homozygous susceptible and...
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