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Article

Variants of the endothelial nitric oxide gene and cerebral blood flow after severe traumatic brain injury.

Journal of neurotrauma - 1 May 2011

Robertson Claudia S, Gopinath Shankar P, Valadka Alex B, Van Mai, Swank Paul R, Goodman J Clay

Abstract excerpt

Experimental studies suggest that nitric oxide produced by endothelial nitric oxide synthase (NOS3) plays a role in maintaining cerebral blood flow (CBF) after traumatic brain injury (TBI). The purpose of this study was to determine if common variants of the NOS3 gene contribute to hypoperfusion after severe TBI. Fifty-one patients with severe TBI were studied. Cerebral hemodynamics, including global CBF by the...

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Source

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Identifiers

PMID: 21332418
DOI: 10.1089/neu.2010.1476
PMCID: PMC3088960

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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