Article
Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish.
Birth defects research. Part A, Clinical and molecular teratology - 1 Mar 2011
Zhang Chengjin, Turton Qwan M, Mackinnon Shanta, Sulik Kathleen K, Cole Gregory J
Abstract excerpt
BACKGROUND: Alcohol (ethanol) is a teratogen known to affect the developing eyes, face, and brain. Among the ocular defects in fetal alcohol spectrum disorder (FASD) are microphthalmia and optic nerve hypoplasia. Employing zebrafish as an FASD model provides an excellent system to analyze the molecular basis of prenatal ethanol exposure-induced defects because embryos can be exposed to ethanol at defined...
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