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Article

A single-tube allele specific-polymerase chain reaction to detect T315I resistant mutation in chronic myeloid leukemia patients.

Journal of hematology & oncology - 8 Feb 2011

Wongboonma Wanwisa, Thongnoppakhun Wanna, Auewarakul Chirayu U

Abstract excerpt

BACKGROUND: BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as one of the most frequent KD mutations, has been shown to be strongly associated with TKI resistance and subsequent therapeutic failure. A simple and sensitive method is thus required to detect...

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Source

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Identifiers

PMID: 21303525
DOI: 10.1186/1756-8722-4-7
PMCID: PMC3045387

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single-tube allele specific-polymerase chain reaction to detect T315I resistant mutation in chronic myeloid leukemia patients.PMID 21303525Read ↗

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