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Article

The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.

Biochimica et biophysica acta - 1 May 2011

Miller Chaya, Wang Liya, Ostergaard Elsebet, Dan Phyllis, Saada Ann

Abstract excerpt

SUCLA2-related mitochondrial DNA (mtDNA) depletion syndrome is a result of mutations in the β subunit of the ADP-dependent isoform of the Krebs cycle succinyl-CoA synthase (SCS). The mechanism of tissue specificity and mtDNA depletion is elusive but complementation by the GDP-dependent isoform encoded by SUCLG2, and the association with mitochondrial nucleoside diphosphate kinase (NDPK), is a plausible link. We...

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Share to Acyl Coenzyme A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21295139
DOI: 10.1016/j.bbadis.2011.01.013

Genes

SUCLA2
SUCLG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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