Article
Serotonin transporter gene (5-HTTLPR) polymorphisms are associated with emotional modulation of pain but not emotional modulation of spinal nociception.
Biological psychology - 1 Mar 2011
Palit Shreela, Sheaff Robert J, France Christopher R, McGlone Sarah T, Potter William T, Harkness Allan R, McNulty John L, Bartley Emily J, Hoffmann Rachel, Monda Julie K, Rhudy Jamie L
Abstract excerpt
The short allele of the serotonin transporter gene (5-HTTLPR) is associated with greater negative emotionality. Given that emotion modulates pain, short allele carriers (s-carriers) may also demonstrate altered pain modulation. The present study used a well-validated emotional picture-viewing paradigm to modulate pain and the nociceptive flexion reflex (NFR, a measure of spinal nociception) in 144 healthy...
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