Article
Pharmacokinetics of cyclophosphamide enantiomers in patients with breast cancer.
Cancer chemotherapy and pharmacology - 1 Oct 2011
Fernandes Bruno José Dumêt, Silva Carolina de Miranda, Andrade Jurandyr Moreira, Matthes Angelo do Carmo Silva, Coelho Eduardo Barbosa, Lanchote Vera Lucia
Abstract excerpt
PURPOSE: Adjuvant chemotherapy with cyclophosphamide (CYC) is used for the treatment of breast cancer. CYC is used as a racemic mixture, although preclinical data have demonstrated differences in the efficacy and toxicity of its enantiomers, with (S)-(-)-CYC exhibiting a higher therapeutic index. The present study investigated the enantioselectivity and influence of CYP2B6, CYP2C9, CYP2C19, and CYP3A on the...
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