Neuroblastomas with discordant genotype-phenotype relationships: report of four cases with MYCN amplification and favorable histology.

doi:10.2350/08-12-0579.1

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Article

Neuroblastomas with discordant genotype-phenotype relationships: report of four cases with MYCN amplification and favorable histology.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000

Nakagawa Atsuko, Matsuoka Kentaro, Okita Hajime, Iwafuchi Hideto, Hori Hisanari, Kumagai Masaaki

Abstract excerpt

MYCN amplification prevents cellular differentiation and promotes mitotic and karyorrhectic activities in neuroblastomas. Hence, MYCN-amplified tumors typically show an appearance of neuroblastoma of either an undifferentiated or a poorly differentiated subtype with a high mitosis-karyorrhexis index. In addition, they are classified as part of the unfavorable histology group, according to the International...

Topics

Adrenal Gland Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Combined Modality Therapy
Female
Gene Amplification
Genotype
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Infant
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

N-Myc Proto-Oncogene Protein

Neoplasm Staging

Neuroblastoma

Nuclear Proteins

Oncogene Proteins

Phenotype

Source

Open in PubMed

Identifiers

PMID: 21288077
DOI: 10.2350/08-12-0579.1

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.