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Article

Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith–Wiedemann syndrome and Silver–Russell syndrome

31 Jan 2011

Abstract excerpt

Hyper- and hypomethylation at the IGF2-H19 imprinting control region (ICR) result in reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders, Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS). DNA methylation of the ICR controls the reciprocal imprinting of IGF2 and H19 by preventing the binding of the insulator protein, CTCF. We here show that local changes in histone...

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PMID: 21282187
DOI: 10.1093/hmg/ddr018

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Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith–Wiedemann syndrome and Silver–Russell syndromePMID 21282187Read ↗

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CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

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