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Mechanisms causing imprinting defects in familial Beckwith–Wiedemann syndrome with Wilms' tumour

11 Dec 2006

Abstract excerpt

The imprinted expression of the IGF2 and H19 genes is controlled by the Imprinting Centre 1 (IC1) at chromosome 11p15.5. This is a methylation-sensitive chromatin insulator that works by binding the zinc-finger protein CTCF in a parent-specific manner. Microdeletions abolishing some of the CTCF target sites (CTSs) of IC1 have been associated with the Beckwith-Wiedemann syndrome (BWS). However, the link between...

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Share to Epigenetics and DNA Methylation
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PMID: 17158821
DOI: 10.1093/hmg/ddl448

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Mechanisms causing imprinting defects in familial Beckwith–Wiedemann syndrome with Wilms' tumourPMID 17158821Read ↗

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