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Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae

28 Oct 2010

Abstract excerpt

ICP-MS analysis of Streptococcus pneumoniae reveals a high cell-associated Mn(II) concentration that is comparable to that of Zn(II). Stressing these cells with 100–200 μM Zn(II) leads to a slow-growth phenotype and a total Mn(II) concentration that is reduced, with no decrease of other metal ions. Supplementation of the growth media with as little as 10 μM Mn(II) fully restores the growth defect and...

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PMID: 21275153
DOI: 10.1039/c0mt00050g

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