Article
Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease: a randomised controlled trial assessing impact upon stopping smoking.
BMC public health - 19 Jan 2011
Whitwell Sophia C L, Mathew Christopher G, Lewis Cathryn M, Forbes Alastair, Watts Sally, Sanderson Jeremy, Hollands Gareth J, Prevost A Toby, Armstrong David, Kinmonth Ann Louise, Sutton Stephen, Marteau Theresa M
Abstract excerpt
BACKGROUND: Estimates of the risk of developing Crohn's disease (CD) can be made using DNA testing for mutations in the NOD2 (CARD15) gene, family history, and smoking status. Smoking doubles the risk of CD, a risk that is reduced by stopping. CD therefore serves as a timely and novel paradigm within which to assess the utility of predictive genetic testing to motivate behaviour change to reduce the risk of...
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