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Article

Functional characterization of mutations in inherited human cPLA₂ deficiency.

Biochemistry - 15 Mar 2011

Reed Kathleen A, Tucker Dawn E, Aloulou Ahmed, Adler David, Ghomashchi Farideh, Gelb Michael H, Leslie Christina C, Oates John A, Boutaud Olivier

Abstract excerpt

Group IVA cytosolic phospholipase A(2) (cPLA(2)α) catalyzes the first step in the arachidonic acid cascade leading to the synthesis of important lipid mediators, the prostaglandins and leukotrienes. We previously described a patient deficient in cPLA(2)α activity, which was associated with mutations in both alleles encoding the enzyme. In this paper, we describe the biochemical characterization of each of these...

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Identifiers

PMID: 21247147
DOI: 10.1021/bi101877n
PMCID: PMC3051024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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