Article
FLT3 inhibitors: a story of the old and the new.
Current opinion in hematology - 1 Mar 2011
Fathi Amir, Levis Mark
Abstract excerpt
PURPOSE OF REVIEW: Ever since the recognition that FMS-like tyrosine kinase 3 (FLT3) mutations exert a profound negative prognostic impact on the clinical outcome of patients with acute myeloid leukemia (AML), researchers have sought to find effective small-molecule inhibitors of this receptor tyrosine kinase. This review will attempt to provide a survey of the FLT3 inhibitors currently under investigation and...
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