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Article

FLT3 inhibitors: a story of the old and the new.

Current opinion in hematology - 1 Mar 2011

Fathi Amir, Levis Mark

Abstract excerpt

PURPOSE OF REVIEW: Ever since the recognition that FMS-like tyrosine kinase 3 (FLT3) mutations exert a profound negative prognostic impact on the clinical outcome of patients with acute myeloid leukemia (AML), researchers have sought to find effective small-molecule inhibitors of this receptor tyrosine kinase. This review will attempt to provide a survey of the FLT3 inhibitors currently under investigation and...

Topics

Acute Disease
Benzothiazoles
Cell Survival
Clinical Trials as Topic
Humans
Leukemia, Myeloid
Mutation
Phenylurea Compounds
Protein Kinase Inhibitors
fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 21245757
DOI: 10.1097/MOH.0b013e3283439a03
PMCID: PMC3082742

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21245757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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