Article
Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods.
Investigative ophthalmology & visual science - 1 Apr 2011
Enriquez-Algeciras Mabel, Ding Di, Chou Tsung-Han, Wang Jianhua, Padgett Kyle R, Porciatti Vittorio, Bhattacharya Sanjoy K
Abstract excerpt
PURPOSE: To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods. METHODS: Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. RESULTS: Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate...
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