Article
AIP mutation in pituitary adenomas in the 18th century and today.
The New England journal of medicine - 6 Jan 2011
Chahal Harvinder S, Stals Karen, Unterländer Martina, Balding David J, Thomas Mark G, Kumar Ajith V, Besser G Michael, Atkinson A Brew, Morrison Patrick J, Howlett Trevor A, Levy Miles J, Orme Steve M, Akker Scott A, Abel Richard L, Grossman Ashley B, Burger Joachim, Ellard Sian, Korbonits Márta
Abstract excerpt
Gigantism results when a growth hormone-secreting pituitary adenoma is present before epiphyseal fusion. In 1909, when Harvey Cushing examined the skeleton of an Irish patient who lived from 1761 to 1783, he noted an enlarged pituitary fossa. We extracted DNA from the patient's teeth and identified a germline mutation in the aryl hydrocarbon-interacting protein gene (AIP). Four contemporary Northern Irish...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.