Article
Pituitary adenoma predisposition caused by germline mutations in the AIP gene.
Science (New York, N.Y.) - 26 May 2006
Vierimaa Outi, Georgitsi Marianthi, Lehtonen Rainer, Vahteristo Pia, Kokko Antti, Raitila Anniina, Tuppurainen Karoliina, Ebeling Tapani M L, Salmela Pasi I, Paschke Ralf, Gündogdu Sadi, De Menis Ernesto, Mäkinen Markus J, Launonen Virpi, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with genealogy data, we identified germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in individuals with pituitary adenoma predisposition (PAP). AIP acts in cytoplasmic retention of the latent form of the aryl hydrocarbon receptor...
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