Article
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.
Molecular and biochemical parasitology - 1 Apr 2011
Ojo Kayode K, Arakaki Tracy L, Napuli Alberto J, Inampudi Krishna K, Keyloun Katelyn R, Zhang Li, Hol Wim G J, Verlinde Christophe L M J, Merritt Ethan A, Van Voorhis Wesley C
Abstract excerpt
Glycogen synthase kinase-3 (GSK-3) is a drug target under intense investigation in pharmaceutical companies and constitutes an attractive piggyback target for eukaryotic pathogens. Two different GSKs are found in trypanosomatids, one about 150 residues shorter than the other. GSK-3 short (GeneDB: Tb927.10.13780) has previously been validated genetically as a drug target in Trypanosoma brucei by RNAi induced...
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