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Article

Real-time quantitative polymerase chain reaction analysis of patients with refractory chronic periodontitis.

Journal of periodontology - 1 Jul 2011

Marconcini Simone, Covani Ugo, Barone Antonio, Vittorio Orazio, Curcio Michele, Barbuti Serena, Scatena Fabrizio, Felli Lamberto, Nicolini Claudio

Abstract excerpt

BACKGROUND: Periodontitis is a complex multifactorial disease and is typically polygenic in origin. Genes play a fundamental part in each biologic process forming complex networks of interactions. However, only some genes have a high number of interactions with other genes in the network and may, therefore, be considered to play an important role. In a preliminary bioinformatic analysis, five genes that showed a...

Topics

Adult
Aggressive Periodontitis
Chronic Periodontitis
Computational Biology
Disease Progression
Female
GRB2 Adaptor Protein
Gene Expression Regulation
Genetic Predisposition to Disease
Glyceraldehyde-3-Phosphate Dehydrogenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

NF-kappa B p50 Subunit

Oncogene Protein v-cbl

Polymerase Chain Reaction

Transcription Factor RelA

Source

Identifiers

PMID: 21189087
DOI: 10.1902/jop.2010.100312

Genes

CBL
GRB2
NFKB1
REL
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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