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HIV-1 Envelope Subregion Length Variation during Disease Progression

16 Dec 2010

Abstract excerpt

The V3 loop of the HIV-1 Env protein is the primary determinant of viral coreceptor usage, whereas the V1V2 loop region is thought to influence coreceptor binding and participate in shielding of neutralization-sensitive regions of the Env glycoprotein gp120 from antibody responses. The functional properties and antigenicity of V1V2 are influenced by changes in amino acid sequence, sequence length and patterns of...

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PMID: 21187897
DOI: 10.1371/journal.ppat.1001228

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