Article
Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia.
Leukemia research - 1 Aug 2011
Maffioli Margherita, Camós Mireia, Gaya Anna, Hernández-Boluda Juan-Carlos, Alvarez-Larrán Alberto, Domingo Abel, Granell Miquel, Guillem Vicent, Vallansot Rolando, Costa Dolors, Bellosillo Beatriz, Colomer Dolors, Cervantes Francisco
Abstract excerpt
The association between seven polymorphisms in the genes hOCT1 and MDR1, encoding for imatinib transporter proteins, and the response to imatinib 400mg/daily was investigated in 65 patients newly diagnosed with chronic-phase chronic myeloid leukemia. The AA genotype at the rs6935207 hOCT1 polymorphic locus was not detected in patients with inadequate response to imatinib. The CC genotype at the rs1045642 (C3435T)...
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